Article

A computational technique to estimate within-host productively infected cell lifetimes in emerging viral infections

2017-03-10

Abstract excerpt

Emerging viruses cause a lot of fatalities as they jump to humans from other species. Here we develop a novel technique to computationally estimate an important parameter of within-host viral infection: the lifespan of infected cells. Our approach is general and can be applied to a large class of viruses and leverages experimental data from replicon studies. Current techniques have difficulties reliably estimating...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a8073038-209c-50b3-924b-e8c107e8a78e
DOI: 10.7287/peerj.preprints.2621v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A computational technique to estimate within-host productively infected cell lifetimes in emerging viral infectionsDOI 10.7287/peerj.preprints.2621v2Read

Quantification of Ebola virus replication kinetics in vitroSemantic proximity Read

Estimating biologically relevant parameters under uncertainty for experimental within-host murine West Nile virus infectionSemantic proximity Read

Dengue virus is sensitive to inhibition prior to productive replication.Semantic proximity Read

In vivo kinetics of SARS-CoV-2 infection and its relationship with a person’s infectiousnessSemantic proximity Read

Kinetics of Asian and African Zika Virus Lineages over Single-cycle and Multi-cycle Growth in Culture: gene expression, cell killing, virus production, and mathematical modelingSemantic proximity Read

Experimentally guided models reveal replication principles that shape the mutation distribution of RNA viruses.Semantic proximity Read

HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation TimeSemantic proximity Read

Modelling the effects of phylogeny and body size on within-host pathogen replication and immune responseSemantic proximity Read

A Novel Antiviral Intervention Results in More Accurate Assessment of Human Immunodeficiency Virus Type 1 Replication Dynamics and T-Cell Decay In VivoSemantic proximity Read

Differential intra-host infection kinetics in Aedes aegypti underlie superior transmissibility of African relative to Asian Zika virusSemantic proximity Read

Viral dynamics in human immunodeficiency virus type 1 infection.Semantic proximity Read

The TEAIV model: Extending the standard TEIV model to account for viral budding ramp upSemantic proximity Read