Article
A robust measure of HIV-1 population turnover within chronically infected individuals.
Molecular biology and evolution - 1 Oct 2004
Achaz G, Palmer S, Kearney M, Maldarelli F, Mellors J W, Coffin J M, Wakeley J
Abstract excerpt
A simple nonparameteric test for population structure was applied to temporally spaced samples of HIV-1 sequences from the gag-pol region within two chronically infected individuals. The results show that temporal structure can be detected for samples separated by about 22 months or more. The performance of the method, which was originally proposed to detect geographic structure, was tested for temporally spaced...
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