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Article

Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2009

Fang Yue, Imagawa Kiwamu, Zhou Xin, Kita Ayako, Sugiura Reiko, Jaiseng Wurentuya, Kuno Takayoshi

Abstract excerpt

Schizosaccharomyces pombe genome contains an essential gene hmg1(+) encoding the sterol biosynthetic enzyme, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR). Here, we isolated an allele of the hmg1(+) gene, hmg1-1/its12, as a mutant that showed sensitivities to high temperature and to FK50...

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Identifiers

PMID: 19486165
DOI: 10.1111/j.1365-2443.2009.01308.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19486165-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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