Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proinsulin-like growth factor-II overexpression does not alter monoallelic H19 gene expression in transfected human embryonic kidney fibroblasts.

Biochemical and biophysical research communications - 16 Feb 1999

Kiess W, Paquette J, Koepf G, Wolf E, Deal C

Abstract excerpt

Insulin-like growth factor-II (IGF-II) is a potent mitogen for cells in culture. The H19 gene is a developmentally regulated gene with putative tumor suppressor activity, and loss of H19 expression may be involved in tumorigenesis. The H19 gene is closely linked to the human IGF-II gene (IGF2) on chromosome 11p15.5 and these genes are reciprocally imprinted in most fetal tissues. H19 is expressed only from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryo, Mammalian
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor II

Share to Kidney

Share to Muscle Proteins

Share to Protein Precursors

Share to RNA, Long Noncoding

Share to RNA, Untranslated

Source

Identifiers

PMID: 10049690
DOI: 10.1006/bbrc.1999.0187

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proinsulin-like growth factor-II overexpression does not alter monoallelic H19 gene expression in transfected human embryonic kidney fibroblasts.PMID 10049690Read ↗

The product of the imprinted H19 gene is an oncofetal RNA.Semantic proximity Read ↗

H19 sense and antisense transgenes modify insulin‐like growth factor‐II mRNA levelsSemantic proximity Read ↗

Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesisSemantic proximity Read ↗

Imprinting and expression of insulin-like growth factor-II and H19 in normal breast tissue and breast tumor.Semantic proximity Read ↗

The expression of the imprinted genes H19 and IGF-2 in choriocarcinoma cell lines. Is H19 a tumor suppressor gene?Semantic proximity Read ↗

Expression, promoter usage and parental imprinting status of insulin-like growth factor II (IGF2) in human hepatoblastoma: uncoupling of IGF2 and H19 imprinting.Semantic proximity Read ↗

Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern.Semantic proximity Read ↗

Loss of imprinting of igf2 in renal-cell carcinomas.Semantic proximity Read ↗

Genomic imprinting of IGF-II and H19 in adult human pancreatic tissues.Semantic proximity Read ↗

The insulin-like growth factor type-2 receptor gene is imprinted in the mouse but not in humans.Semantic proximity Read ↗

Expression of the imprinted gene H19 in the human fetusSemantic proximity Read ↗

Monoallelic expression of the human H19 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.