Article
Broadly applicable TCR-based therapy for multiple myeloma targeting the immunoglobulin J chain.
Journal of hematology & oncology - 27 Feb 2023
Meeuwsen Miranda H, Wouters Anne K, Wachsmann Tassilo L A, Hagedoorn Renate S, Kester Michel G D, Remst Dennis F G, van der Steen Dirk M, de Ru Arnoud H, van Hees Els P, Kremer Martijn, Griffioen Marieke, van Veelen Peter A, Falkenburg J H Frederik, Heemskerk Mirjam H M
Abstract excerpt
BACKGROUND: The immunoglobulin J chain (Jchain) is highly expressed in the majority of multiple myeloma (MM), and Jchain-derived peptides presented in HLA molecules may be suitable antigens for T-cell therapy of MM. METHODS: Using immunopeptidomics, we identified Jchain-derived epitopes presented by MM cells, and pHLA tetramer technology was used to isolate Jchain-specific T-cell clones. RESULTS: We identified T...
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