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Article

Regulation of cardiac L-type Ca2+ channel by coexpression of G(alpha s) in Xenopus oocytes.

FEBS letters - 5 Feb 1999

Blumenstein Y, Ivanina T, Shistik E, Bossi E, Peres A, Dascal N

Abstract excerpt

Activation of G(alpha s) via beta-adrenergic receptors enhances the activity of cardiac voltage-dependent Ca2+ channels of the L-type, mainly via protein kinase A (PKA)-dependent phosphorylation. Contribution of a PKA-independent effect of G(alpha s) has been proposed but remains controversial. We demonstrate that, in Xenopus oocytes, antisense knockdown of endogenous G(alpha s) reduced, whereas coexpression of...

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Share to Adrenergic beta-2 Receptor Agonists
Share to Calcium Channels, L-Type

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits, Gs

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Share to Receptors, Adrenergic, beta-2

Source

Identifiers

PMID: 10037152
DOI: 10.1016/s0014-5793(99)00035-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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