Article
Apolipoprotein E epsilon 4 allele and Japanese late-onset depressive disorders.
Biological psychiatry - 1 Feb 1999
Ohara K, Nagai M, Suzuki Y, Yoshida K, Tsukamoto T, Ohara K
Abstract excerpt
BACKGROUND: Several studies have suggested that late-onset depressive disorder (LOD) and the apolipoprotein E (Apo E) epsilon 4 allele are associated with dementia, respectively. The Apo E polymorphism is significantly heterogeneous among races. We hypothesized that the Apo E epsilon 4 allele frequency is elevated in Japanese LOD. METHODS: The Apo E genotype was studied in 134 patients (male, 53; female, 81) with...
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