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Article

Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding.

Communications biology - 6 Mar 2020

Huang Bill X, Hu Xin, Kwon Heung-Sun, Fu Cheng, Lee Ji-Won, Southall Noel, Marugan Juan, Kim Hee-Yong

Abstract excerpt

Adhesion G protein-coupled receptors (aGPCR) are characterized by a large extracellular region containing a conserved GPCR-autoproteolysis-inducing (GAIN) domain. Despite their relevance to several disease conditions, we do not understand the molecular mechanism by which aGPCRs are physiologically activated. GPR110 (ADGRF1) was recently deorphanized as the functional receptor of N-docosahexaenoylethanolamine...

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Oncogene Proteins
Ethanolamines
HEK293 Cells
Ligands
Molecular Docking Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Domains

Receptors, G-Protein-Coupled

Structure-Activity Relationship

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Identifiers

PMID: 32144388
DOI: 10.1038/s42003-020-0831-6
PMCID: PMC7060178

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