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Article

Activation of Adhesion G Protein-coupled Receptors: AGONIST SPECIFICITY OF STACHEL SEQUENCE-DERIVED PEPTIDES.

The Journal of biological chemistry - 17 Mar 2017

Demberg Lilian M, Winkler Jana, Wilde Caroline, Simon Kay-Uwe, Schön Julia, Rothemund Sven, Schöneberg Torsten, Prömel Simone, Liebscher Ines

Abstract excerpt

Members of the adhesion G protein-coupled receptor (aGPCR) family carry an agonistic sequence within their large ectodomains. Peptides derived from this region, called the Stachel sequence, can activate the respective receptor. As the conserved core region of the Stachel sequence is highly similar between aGPCRs, the agonist specificity of Stachel sequence-derived peptides was tested between family members using...

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Identifiers

PMID: 28154189
DOI: 10.1074/jbc.M116.763656
PMCID: PMC5377759

Genes

ADGRF1
ADGRF5
ADGRG2
ADGRG6

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