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Article

Case Report: Endothelial-targeted bridging therapy for a TTP-like phenotype in fulminant iMCD-TAFRO.

Frontiers in immunology - 1 Jan 2026

Du Jing, Wu Liangliang, Li Haigang, Gan Haibo, Yu Tao, Xie Shuangfeng, Fang Xiangshao

Abstract excerpt

Background: iMCD-TAFRO (the TAFRO clinical subtype of idiopathic multicentric Castleman disease (iMCD)) is characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly. Diagnosis is challenging due to its rarity, non-specific early presentation, and overlap with sepsis, lymphoma, and thrombotic microangiopathy (TMA). Endothelial injury is increasingly recognized as a central driver of...

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Identifiers

PMID: 41836447
DOI: 10.3389/fimmu.2026.1776382
PMCID: PMC12979455

Genes

ADAMTS13

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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