Article

Pathogenic measles viruses cannot evolve to bypass vaccine-induced neutralizing antibodies

2020-10-23

Abstract excerpt

After centuries of pestilence and decades of global vaccination, measles serotypes capable of evading vaccine-induced immunity have not emerged. Here, by systematically building mutations into the H-glycoprotein of an attenuated measles strain and assaying for serum neutralization, we show that virus evolution is severely constrained by the existence of numerous codominant H-glycoprotein antigenic sites, some crit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ffcbb88c-e40b-5800-886a-4e8f27b143b5
DOI: 10.1101/2020.10.22.351189

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pathogenic measles viruses cannot evolve to bypass vaccine-induced neutralizing antibodiesDOI 10.1101/2020.10.22.351189Read

Serotypic evolution of measles virus is constrained by multiple co-dominant B cell epitopes on its surface glycoproteinsSemantic proximity Read

Mutational Analysis of Measles Virus Suggests Constraints on Antigenic Variation of the GlycoproteinsSemantic proximity Read

Epitope dampening monotypic measles virus hemagglutinin glycoprotein results in resistance to cocktail of monoclonal antibodies.Semantic proximity Read

Understanding the Measles Virus at 70 Years: From Cellular Mechanisms to Immunisation, 1954-2024Semantic proximity Read

Surface-modified measles vaccines encoding oligomeric, fusion-stabilized SARS-CoV-2 spike glycoproteins bypass measles seropositivity, boosting neutralizing antibody responses to omicron and historical variantsSemantic proximity Read

A hierarchical activation threshold shapes RSV F antibody repertoires from toddler vulnerability to adult protectionSemantic proximity Read

Measles Virus Hemagglutinin epitopes immunogenic in natural infection and vaccination are targeted by broad or genotype-specific neutralizing monoclonal antibodies.Semantic proximity Read

Emergent lineages of mumps virus suggest the need for a polyvalent vaccineSemantic proximity Read

Virology of measles virus.Semantic proximity Read

Seroprevalence of measles-specific IgG and genotype-specific neutralizing antibody responses in clinically confirmed cases during the 2021–2023 measles outbreaks in LiberiaSemantic proximity Read

Acute induction of IFNα is responsible for the attenuation of the live measles vaccineSemantic proximity Read

A single amino acid mutation in norovirus NS4 promotes viral spread.Semantic proximity Read