Article

Acute induction of IFNα is responsible for the attenuation of the live measles vaccine

2025-06-09

Abstract excerpt

The live-attenuated measles vaccine (LAMV) protects against measles in a safe, efficacious and durable manner. However, the mechanism by which LAMV is attenuated is not well understood, contributing to the increased vaccine hesitancy that has caused a worldwide resurgence of measles. Here, we provide a molecular model of attenuation that implicates increased host innate immune responses and increased LAMV suscepti...

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Literature Corpus work: 090b68f7-3841-54be-8a08-f7357ebe22a2
DOI: 10.1101/2025.06.09.658652

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