Serotypic evolution of measles virus is constrained by multiple co-dominant B cell epitopes on its surface glycoproteins

Abstract excerpt

After centuries of pestilence and decades of global vaccination, measles virus (MeV) genotypes capable of evading vaccine-induced immunity have not emerged. Here, by systematically building mutations into the hemagglutinin (H) glycoprotein of an attenuated measles virus strain and assaying for serum neutralization, we show that virus evolution is severely constrained by the existence of numerous co-dominant H...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Respiratory viral infections research
• Share to SARS-CoV-2 and COVID-19 Research
• Share to Virology and Viral Diseases