Article

Glycolysis and hexosamine biosynthesis pathways are key for inflammatory protein maturation and leukocyte adhesion to human aortic valve cells

2025-12-15

Abstract excerpt

<h4>ABSTRACT</h4> Inflammation and metabolism reprogramming are hallmarks of calcific aortic valve disease (CAVD). Recent studies link inflammation to hyperglycolysis and calcification in valve interstitial cells (VICs). The metabolism of valve endothelial cells (VECs) has received less attention despite both resident valve cells are exposed to alike inflammatory clues involved in the biosynthesis of pathological...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ffc5dfe3-19ba-5c8c-ae82-6dc39cfc9cd1
DOI: 10.64898/2025.12.12.693904

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glycolysis and hexosamine biosynthesis pathways are key for inflammatory protein maturation and leukocyte adhesion to human aortic valve cellsDOI 10.64898/2025.12.12.693904Read

Lumican promotes calcific aortic valve disease through H3 histone lactylationSemantic proximity Read

Identification of a peripheral blood gene signature predicting aortic valve calcificationSemantic proximity Read

An H3K18la-ALKBH5-Runx2-LDHA positive feedback loop promotes vascular calcification in the osteogenic phenotypic transition of vascular smooth muscle cells.Semantic proximity Read

Single-Cell Transcriptomic Profiling Unveils Critical Metabolic Alterations and Signatures in Progression of AtherosclerosisSemantic proximity Read

Identification of key genes and pathways in calcific aortic valve disease by bioinformatics analysisSemantic proximity Read

The Complex Interplay of Inflammation, Metabolism, Epigenetics, and Sex in Calcific Disease of the Aortic ValveSemantic proximity Read

A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profilingSemantic proximity Read

Fructose utilization by GM-CSF-differentiated macrophages aggravates autoimmune inflammation <i>via</i> MG-derived AGE–RAGE signalingSemantic proximity Read

Patient-Derived Circulating Monocytes Promote Calcific Aortic Valve Disease ProgressionSemantic proximity Read

Lactylation associated biomarkers and immune infiltration in aortic dissectionSemantic proximity Read

Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰Semantic proximity Read

The Complex Relationship between Hypoxia Signaling, Mitochondrial Dysfunction and Inflammation in Calcific Aortic Valve Disease: Insights from the Molecular Mechanisms to Therapeutic ApproachesSemantic proximity Read