Article

Binocular Benefit Following Monocular Subretinal AAV Injection in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa (adRP)

2021-07-22

Abstract excerpt

Autosomal dominant retinitis pigmentosa (adRP) is frequently caused by mutations in RHO , the gene for rhodopsin. In previous experiments in dogs with the T4R mutation in RHO , an AAV2/5 vector expressing both an shRNA directed to human and dog RHO mRNA and an shRNA-resistant human RHO cDNA (AAV- RHO820-shRNA820 ) prevented retinal degeneration for more than 8 months following injection. To confirm that this...

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Literature Corpus work: ffa927d0-5b44-56e9-8373-2011ae35fb2d
DOI: 10.1101/2021.07.22.453413

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