Article
Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.
Nucleic acids research - 9 Jul 2021
Lang Benjamin, Yang Jae-Seong, Garriga-Canut Mireia, Speroni Silvia, Aschern Moritz, Gili Maria, Hoffmann Tobias, Tartaglia Gian Gaetano, Maurer Sebastian P
Abstract excerpt
RNA-binding proteins (RBPs) are crucial factors of post-transcriptional gene regulation and their modes of action are intensely investigated. At the center of attention are RNA motifs that guide where RBPs bind. However, sequence motifs are often poor predictors of RBP-RNA interactions in vivo. It is hence believed that many RBPs recognize RNAs as complexes, to increase specificity and regulatory possibilities....
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