Article

2-phenylacetylsulfonamide promotes apoptosis of hepatocellular carcinoma by inhibiting HSP70 through PI3K/AKT signaling pathway

2026-05-06

Abstract excerpt

<title>Abstract</title> <p>Heat shock proteins (HSPs) are found widely across various organisms and play a crucial role in tumor and malignancy formation. Among all HSPs, HSP70 is the most extensively researched. 2-phenylacetylsulfonamide (PES) is a covalent inhibitor of HSP70, which has a significant effect on inhibiting wide range of cancer cells. Nevertheless, the effects of PES on hepatocellular carcinoma (HC...

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Literature Corpus work: ff5ed033-60dc-5929-ac20-5fa9d483091c
DOI: 10.21203/rs.3.rs-8501296/v1

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