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Article

PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain.

The Journal of biological chemistry - 1 Jan 2000

Yang Jie, Gong Weibin, Wu Si, Zhang Hong, Perrett Sarah

Abstract excerpt

Hsp70 proteins are a family of ancient and conserved chaperones. They play important roles in vital cellular processes, such as protein quality control and the stress response. Hsp70 proteins are a potential drug target for treatment of disease, particularly cancer. PES (2-phenylethynesulfonamide or pifithrin-μ) has been reported to be an inhibitor of Hsp70. However, the mechanism of PES inhibition is still...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33835030
DOI: 10.1074/jbc.RA120.015440
PMCID: PMC7948744

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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