Article

Using regions of homozygosity to evaluate the use of dogs as preclinical models in human drug development

2020-01-09

Abstract excerpt

Animals are used as preclinical models for human diseases in drug development. Dogs, especially, are used in preclinical research to support the clinical safety evaluations during drug development. Comparisons of patterns of regions of homozygosity (ROH) and phenotypes between dog and human are not well known. We conducted a genome-wide homozygosity analysis (GWHA) in the human and the dog genomes. We calculated R...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ff4a3e4b-c30e-54bc-aa2e-f2115e617c69
DOI: 10.1101/2020.01.08.898916

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Using regions of homozygosity to evaluate the use of dogs as preclinical models in human drug developmentDOI 10.1101/2020.01.08.898916Read

Using Regions of Homozygosity to Evaluate the Use of Dogs as Preclinical Models in Human Drug DevelopmentSemantic proximity Read

Genetic prevalence and clinical relevance of canine Mendelian disease variants in over one million dogsSemantic proximity Read

The impact of identity-by-descent on fitness and disease in natural and domesticated <i>Canid</i> populationsSemantic proximity Read

Fine-scale resolution and analysis of runs of homozygosity in domestic dogsSemantic proximity Read

Dog-human translational genomics: state of the art and genomic resources.Semantic proximity Read

The impact of identity by descent on fitness and disease in dogs.Semantic proximity Read

Genetic prevalence and clinical relevance of canine Mendelian disease variants in over one million dogs.Semantic proximity Read

Web resource on available DNA variant tests for hereditary diseases and genetic predispositions in dogs and cats: An Update.Semantic proximity Read

Genetic diversity and runs of homozygosity (ROH): A portrait of the quantitative academic publication dynamic and scientific metadataSemantic proximity Read

Insights into morphology and disease from the dog genome project.Semantic proximity Read

Blood biomarkers and breed genetics of aging in pet dogsSemantic proximity Read

Genetic dissection of behavioral traits related to successful training of drug detection dogs.Semantic proximity Read