Article

Using Regions of Homozygosity to Evaluate the Use of Dogs as Preclinical Models in Human Drug Development

2020-05-15

Abstract excerpt

BACKGROUND Animals are used as preclinical models for human diseases in drug development. Dogs, especially, are used in preclinical research to support the clinical safety evaluations during drug development. Comparisons of patterns of regions of homozygosity (ROH) and phenotypes between dog and human are not well known. We conducted a genome-wide homozygosity analysis (GWHA) in the human and the dog genomes. RESU...

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Literature Corpus work: 64444f6c-f64c-57a1-8d2c-b257953b214c
DOI: 10.21203/rs.3.rs-27728/v1

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