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Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles

2024-12-05

Abstract excerpt

<h4>ABSTRACT</h4> Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) have emerged as promising and safe therapeutic agents, however, donor heterogeneities, limited replicative life span and changes in the cellular phenotype throughout in vitro cultivation remain major hurdles for scalable EV production. For these reasons, this study aims to investigate the use of hTERT immortalized (‘telomerized’)...

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Literature Corpus work
ff47730e-baad-5879-8757-9e67530c826b
DOI
10.1101/2024.12.05.626964
Open publication

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Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesiclesDOI 10.1101/2024.12.05.626964
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