Article

Engineering Mesenchymal Stem Cells to Extend Healthspan: Therapeutic Potential, Challenges, and Future Solutions

2026-06-30

Abstract excerpt

Engineered mesenchymal stem cells (MSCs) have emerged as a promising therapeutic platform for extending healthspan. As agents of tissue repair and modulators of biological aging, MSCs have been widely studied for their capacity to enhance regeneration, restore immune homeostasis, and reduce chronic inflammation associated with age-related decline. This review examines emerging bioengineering strategies designed to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7f49b14e-1a87-5f60-9d99-c5e06667067a
DOI: 10.20944/preprints202606.2068.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Engineering Mesenchymal Stem Cells to Extend Healthspan: Therapeutic Potential, Challenges, and Future SolutionsDOI 10.20944/preprints202606.2068.v1Read

Cell and Cell-Free Therapies to Counteract Human Premature and Physiological Aging: MSCs Come to LightSemantic proximity Read

Engineered Extracellular Vesicles from Adipose-Derived Stem Cells: Translational Strategies from Genetic Engineering to Scalable ProductionSemantic proximity Read

Aging and Mesenchymal Stem Cells: Basic Concepts, Challenges and StrategiesSemantic proximity Read

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of agingSemantic proximity Read

Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and ChallengesSemantic proximity Read

Advances in mesenchymal stem cell and exosome-based therapies for aging and age-related diseasesSemantic proximity Read

Human ESC‐sEVs alleviate age‐related bone loss by rejuvenating senescent bone marrow‐derived mesenchymal stem cellsSemantic proximity Read

Extracellular Vesicles from Senescent Stem Cells: A Converging Nexus Between Aging, Regeneration, and CancerSemantic proximity Read

Stress-induced senescence in mesenchymal stem cells: Triggers, hallmarks, and current rejuvenation approachesSemantic proximity Read

Molecular Mechanisms Contributing to Mesenchymal Stromal Cell AgingSemantic proximity Read

Potential applications of mesenchymal stem cells and their derived exosomes in regenerative medicineSemantic proximity Read

Mesenchymal Stem Cell Senescence during Aging:From Mechanisms to Rejuvenation StrategiesSemantic proximity Read