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Mesenchymal stromal cell-derived extracellular vesicles: novel approach in hematopoietic stem cell transplantation

16 May 2022

Abstract excerpt

Bone marrow mesenchymal stromal cells (MSCs) play a crucial role in the regulation of hematopoiesis. These cells affect the process through direct cell-cell contact, as well as releasing various trophic factors and extracellular vehicles (EVs) into the bone marrow microenvironment. MSC-derived EVs (MSC-EVs) are prominent intercellular communication tolls enriched with broad-spectrum bioactive factors such as...

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PMID: 35578300
DOI: 10.1186/s13287-022-02875-3

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