Article

Puzzles in modern biology. IV. Neurodegeneration, localized origin and widespread decay

2016-10-19

Abstract excerpt

The motor neuron disease amyotrophic lateral sclerosis (ALS) typically begins with localized muscle weakness. Progressive, widespread paralysis often follows over a few years. Does the disease begin with local changes in a small piece of neural tissue and then spread? Or does neural decay happen independently across diverse spatial locations? The distinction matters, because local initiation may arise by local cha...

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Literature Corpus work: ff1c9a4e-7c6c-52c8-86a2-cfed1ac12bed
DOI: 10.12688/f1000research.9790.1

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