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Article

The "somatic-spread" hypothesis for sporadic neurodegenerative diseases.

Medical hypotheses - 1 Oct 2011

Pamphlett Roger

Abstract excerpt

The major neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis) share in common a mostly sporadic occurrence, a focal onset of pathology, and spread from the initial site of injury to adjacent regions of the nervous system. The sporadic nature and focal onset of these diseases can be explained either by somatic mutations (arising in either of two models of cell...

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PMID: 21726962
DOI: 10.1016/j.mehy.2011.06.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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