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Article

Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming.

Communications biology - 23 Apr 2020

Solé-Boldo Llorenç, Raddatz Günter, Schütz Sabrina, Mallm Jan-Philipp, Rippe Karsten, Lonsdorf Anke S, Rodríguez-Paredes Manuel, Lyko Frank

Abstract excerpt

Fibroblasts are an essential cell population for human skin architecture and function. While fibroblast heterogeneity is well established, this phenomenon has not been analyzed systematically yet. We have used single-cell RNA sequencing to analyze the transcriptomes of more than 5,000 fibroblasts from a sun-protected area in healthy human donors. Our results define four main subpopulations that can be spatially...

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Identifiers

PMID: 32327715
DOI: 10.1038/s42003-020-0922-4
PMCID: PMC7181753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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