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Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer

18 Oct 2023

Abstract excerpt

Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their behavior is regulated through a complex interplay of networks, including transcriptional, post-transcriptional, epigenetic, tumor microenvironment (TME), and epithelial-mesenchymal transition (EMT) factors. Numerous signaling pathways...

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PMID: 37853437
DOI: 10.1186/s12943-023-01877-w

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