Article

Position-specific evolution in transcription factor binding sites, and a fast likelihood calculation for the F81 model

2023-07-25

Abstract excerpt

Transcription factor binding sites (TFBS), like other DNA sequence, evolve via mutation and selection relating to their function. Models of nucleotide evolution describe DNA evolution via single-nucleotide mutation. A stationary vector of such a model is the long-term distribution of nucleotides, unchanging under the model. Neutrally evolving sites may have uniform stationary vectors, but one expects that sites wi...

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Identifiers and source

Literature Corpus work: fee705b0-8ad9-5ea2-bc74-7ef18779970e
DOI: 10.1101/2023.07.23.550199

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