Article

Gene Transfer to the Outflow Tract

2016-03-17

Abstract excerpt

Elevated intraocular pressure is the primary cause of open angle glaucoma. Outflow resistance exists within the trabecular meshwork but also at the level of Schlemm′s canal and further downstream within the outflow system. Viral vectors allow to take advantage of naturally evolved, highly efficient mechanisms of gene transfer, a process that is termed transduction. They can be produced at biosafety level 2 in the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fed6537f-3bca-5fa1-9ef2-e74f33a3f5c0
DOI: 10.1101/044396

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene Transfer to the Outflow TractDOI 10.1101/044396Read

Genetic Modification of Human Trabecular Meshwork with Lentiviral VectorsSemantic proximity Read

The concept of gene therapy for glaucomaSemantic proximity Read

Mechanisms of AAV transduction in glaucoma‐associated human trabecular meshwork cellsSemantic proximity Read

Reverse engineering glaucomaSemantic proximity Read

Long-Term, Targeted Genetic Modification of the Aqueous Humor Outflow Tract Coupled with Noninvasive Imaging of Gene Expression In VivoSemantic proximity Read

Gene Therapy in the Anterior Eye SegmentSemantic proximity Read

Transduction optimization of AAV vectors for human gene therapy of glaucoma and their reversed cell entry characteristicsSemantic proximity Read

Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat.Semantic proximity Read

Durable, Safe, Multi-gene Lentiviral Vector Expression in Feline Trabecular MeshworkSemantic proximity Read

Adenoviral Gene Transfer of Active Human Transforming Growth Factor-β2 Elevates Intraocular Pressure and Reduces Outflow Facility in Rodent EyesSemantic proximity Read

Expression Analysis of the Matrix GLA Protein and VE-Cadherin Gene Promoters in the Outflow PathwaySemantic proximity Read

Inducible scAAV2.GRE.MMP1 lowers IOP long-term in a large animal model for steroid-induced glaucoma gene therapySemantic proximity Read