Article

Co-infection with two α-synuclein strains reveals novel synergistic interactions

2025-08-22

Abstract excerpt

<h4>ABSTRACT</h4> In synucleinopathies, the protein α-synuclein misfolds into Lewy bodies (LBs) in patients with Lewy body disease (LBD) or into glial cytoplasmic inclusions (GCIs) in patients with multiple system atrophy (MSA). The ability of a single misfolded protein to cause disparate diseases is explained by the prion strain hypothesis, which argues that protein conformation is a major determinant of disease...

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Literature Corpus work: fead824e-625c-59ce-b7e8-d6823e557baf
DOI: 10.1101/2025.08.17.670736

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