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Multiple system atrophy: α-Synuclein strains at the neuron-oligodendrocyte crossroad

26 Nov 2022

Abstract excerpt

The aberrant accumulation of α-Synuclein within oligodendrocytes is an enigmatic, pathological feature specific to Multiple system atrophy (MSA). Since the characterization of the disease in 1969, decades of research have focused on unravelling the pathogenic processes that lead to the formation of oligodendroglial cytoplasmic inclusions. The discovery of aggregated α-Synuclein (α-Syn) being the primary...

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PMID: 36435784
DOI: 10.1186/s13024-022-00579-z

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