Article

Functional study of the AMD-associated gene <i>TMEM97</i> in retinal pigmented epithelium using CRISPR interference

2020-07-11

Abstract excerpt

Age-related macular degeneration (AMD) is a blinding disease characterised by dysfunction of the retinal pigmented epithelium (RPE) which culminates in disruption or loss of the neurosensory retina. Genome-wide association studies have identified >65 genetic risk factors for AMD, including the TMEM97 locus. TMEM97 encodes the Sigma-2 receptor which is involved in apoptosis and cytotoxicity across a range of neur...

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Literature Corpus work: fe9ba933-aaa7-51d4-9e1b-4522e68d61d3
DOI: 10.1101/2020.07.10.198143

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