Article

A Two-Sample Robust Bayesian Mendelian Randomization Method Accounting for Linkage Disequilibrium and Idiosyncratic Pleiotropy with Applications to the COVID-19 Outcome

2021-03-05

Abstract excerpt

<h4>ABSTRACT</h4> Mendelian randomization (MR) is a statistical method exploiting genetic variants as instrumental variables to estimate the causal effect of modifiable risk factors on an outcome of interest. Despite wide uses of various popular two-sample MR methods based on genome-wide association study summary level data, however, those methods could suffer from potential power loss or/and biased inference when...

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Literature Corpus work: fe87c9f5-e4a9-5081-8dd1-9f6c33f27d72
DOI: 10.1101/2021.03.02.21252801

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