Article

HCMV infection depends on EGLN1-mediated mitochondrial activation to increase dNTP pools for viral DNA replication

2025-10-31

Abstract excerpt

Human cytomegalovirus (HCMV) is a leading cause of congenital infection and morbidity in immunosuppressed populations. Like all viruses, HCMV is an obligate intracellular parasite that extensively remodels host cellular metabolism to support its replication, yet the precise underlying mechanisms and metabolic vulnerabilities remain poorly understood. Using a novel metabolism-focused screening platform, we identifi...

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Literature Corpus work: 78011d39-47a5-5b5b-b225-62c012bacb19
DOI: 10.1101/2025.10.31.685607

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