Article

ERBB2 deficiency enhances colorectal cancer progression through EGFR-dependent compensatory mechanisms

2026-04-02

Abstract excerpt

<title>Abstract</title> <p> <italic>ERBB2</italic> is mutated or amplified in a subset of colorectal cancers (CRCs) and may be a marker of resistance to anti-epidermal growth factor receptor (EGFR) therapeutics and help to identify patients who may benefit from ERBB2-directed therapeutic management. To further investigate the role of ERBB2, we generated a population of <italic>Erbb2</italic> -deficient <ital...

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Literature Corpus work: fe69319f-72d5-55f5-a03f-9971c9974304
DOI: 10.21203/rs.3.rs-8802187/v1

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