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Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis

30 Jul 2021

Abstract excerpt

The etiology and pathogenesis of "anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis" and the role of autoantibodies (AB) in this condition are still obscure. While NMDAR1-AB exert NMDAR-antagonistic properties by receptor internalization, no firm evidence exists to date that NMDAR1-AB by themselves induce brain inflammation/encephalitis. NMDAR1-AB of all immunoglobulin classes are highly frequent across...

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PMID: 34331009
DOI: 10.1038/s41380-021-01238-3

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