Article
Circulating cardiomyocyte-derived extracellular vesicles reflect cardiac injury during systemic inflammatory response syndrome in mice.
Cellular and molecular life sciences : CMLS - 20 Jan 2022
Hegyesi Hargita, Pallinger Éva, Mecsei Szabina, Hornyák Balázs, Kovácsházi Csenger, Brenner Gábor B, Giricz Zoltán, Pálóczi Krisztina, Kittel Ágnes, Tóvári József, Turiak Lilla, Khamari Delaram, Ferdinandy Péter, Buzás Edit I
Abstract excerpt
The release of extracellular vesicles (EVs) is increased under cellular stress and cardiomyocyte damaging conditions. However, whether the cardiomyocyte-derived EVs eventually reach the systemic circulation and whether their number in the bloodstream reflects cardiac injury, remains unknown. Wild type C57B/6 and conditional transgenic mice expressing green fluorescent protein (GFP) by cardiomyocytes were studied...
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