Article

Pregnancy-associated plasma protein-A drives melanoma metastasis and immune evasion via IGF signaling

2025-09-23

Abstract excerpt

<title>Abstract</title> <p> Background Melanoma is one of the most common cancers diagnosed during pregnancy. Pregnancy-associated plasma protein-A (PAPPA) is a secreted metalloproteinase that increases local insulin-like growth factor (IGF) bioavailability via proteolytic cleavage of IGF-binding protein 4 (IGFBP-4) to induce PI3K/AKT signaling. While the PAPPA/IGF axis has been implicated in tumor progression o...

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Literature Corpus work: fe5a7522-e7e0-51fe-a0e3-d85b542ad069
DOI: 10.21203/rs.3.rs-7513701/v1

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