Back to search

Article

Pyronaridine Protects Against SARS-CoV-2 in Mouse

2021-09-30

Abstract excerpt

There are currently relatively few small-molecule antiviral drugs that are either approved or emergency approved for use against SARS-CoV-2. One of these is remdesivir, which was originally repurposed from its use against Ebola and functions by causing early RNA chain termination. We used this as justification to evaluate three molecules we had previously identified computationally with antiviral activity against...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e4aeb014-130f-50d7-a2fc-1c49cb3ca32f
DOI
10.1101/2021.09.30.462449
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Pyronaridine Protects Against SARS-CoV-2 in MouseDOI 10.1101/2021.09.30.462449
A vimentin-targeting oral compound with host-directed antiviral and anti-inflammatory actions addresses multiple features of COVID-19 and related diseasesSemantic proximity
Anthracyclines inhibit SARS-CoV-2 infectionSemantic proximity
Small molecules in the treatment of COVID-19Semantic proximity
Potential Therapeutic Agents and Associated Bioassay Data for COVID-19 and Related Human Coronavirus InfectionsSemantic proximity
Intranasal Administration of ACIS KEPTIDE™ Prevents SARS-CoV2-Induced Acute Toxicity in K18-hACE2 Humanized Mouse Model of COVID-19: A Mechanistic Insight for the Prophylactic Role of KEPTIDE™ in COVID-19Semantic proximity
CNP blocks mitochondrial depolarization and inhibits SARS-CoV-2 replication <i>in vitro</i> and <i>in vivo</i>Semantic proximity
Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in miceSemantic proximity
ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathologySemantic proximity
ACE2 is the critical <i>in vivo</i> receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathologySemantic proximity
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.Semantic proximity
Targeting conserved regions of the SARS-CoV-2 polymerase (RdRp) with kinase inhibitors as an effective new tactic for discovering dual-action "antiviral–antiinflammatory" drugs against COVID-19Semantic proximity
Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19Semantic proximity
Select a neighboring publication to make it the new centre.