Article
Statistical issues and approaches in endophenotype research.
2011-11-01
Abstract excerpt
The endophenotype concept was initially proposed to enhance the power of genetic studies of complex disorders. It is closely related to the genetic component in a liability-threshold model; a perfect endophenotype should have a correlation of 1 with the genetic component of the liability to disease. In reality, a putative endophenotype is unlikely to be a perfect representation of the genetic component of disease...
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Identifiers and source
- Literature Corpus work
- fdf9b8e3-f7e1-5a73-ac0b-dad4e19af501
- DOI
- 10.1007/s11434-011-4746-y