Article

Development and validation of inducible protein degradation and quantitative phosphoproteomics to identify kinase-substrate relationships

2021-12-10

Abstract excerpt

Phosphorylation signaling is an essential post-translational regulatory mechanism that governs almost all eukaryotic biological processes and is controlled by an interplay between protein kinases and phosphatases. Knowledge of direct substrates of kinases provides evidence of mechanisms that relate activity to biological function. Linking kinases to their protein substrates can be achieved by inhibiting or reducin...

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Literature Corpus work: fda823f5-dcb7-5fcd-aef3-5db5fc49b2ce
DOI: 10.1101/2021.12.08.471812

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