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Article

Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA).

Scientific reports - 23 Jan 2014

Thangavelu K, Chong Qing Yun, Low Boon Chuan, Sivaraman J

Abstract excerpt

Glutaminase is a metabolic enzyme responsible for glutaminolysis, a process harnessed by cancer cells to feed their accelerated growth and proliferation. Among the glutaminase isoforms, human kidney-type glutaminase (KGA) is often upregulated in cancer and is thus touted as an attractive drug target. Here we report the active site inhibition mechanism of KGA through the crystal structure of the catalytic domain...

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Identifiers

PMID: 24451979
DOI: 10.1038/srep03827
PMCID: PMC4929687

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