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Article

Increased RNA editing in maternal immune activation model of neurodevelopmental disease

16 Oct 2020

Abstract excerpt

The etiology of major neurodevelopmental disorders such as schizophrenia and autism is unclear, with evidence supporting a combination of genetic factors and environmental insults, including viral infection during pregnancy. Here we utilized a mouse model of maternal immune activation (MIA) with the viral mimic PolyI:C infection during early gestation. We investigated the transcriptional changes in the brains of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33067431
DOI: 10.1038/s41467-020-19048-6

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