Article

Embryonic and adult synaptic proteome perturbations after maternal immune activation: Identification of persistent changes relevant for early intervention

2023-07-03

Abstract excerpt

<title>Abstract</title> <p>Maternal infections during pregnancy pose an increased risk for neurodevelopmental psychiatric disorders (NPDs) in the offspring. Here, we examined age- and sex-dependent dynamic changes of the hippocampal synaptic proteome after maternal immune activation (MIA) in embryonic and adult mice. Adult male and female MIA offspring exhibited social deficits and sex-specific depression-like be...

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Literature Corpus work: 28b8f8e2-df7d-5904-ad87-f4b710067e03
DOI: 10.21203/rs.3.rs-3100753/v1

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