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Lithium carbonate in Amyotrophic Lateral Sclerosis patients homozygous for the C-allele at SNP rs12608932 in UNC13A; protocol for a confirmatory, randomized, group-sequential, event-driven, double-blind, placebo-controlled trial.

2022-10-04

Abstract excerpt

<title>Abstract</title> Background Given the large genetic heterogeneity in Amyotrophic Lateral Sclerosis (ALS), it seems likely that genetic subgroups may benefit differently from treatment. An exploratory meta-analysis identified that patients homozygous for the C-allele at SNP rs12608932, a single nucleotide polymorphism in the gene <italic>UNC13A</italic>, had a statistically significant survival benefit...

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Literature Corpus work: fd700954-aa06-57e6-9fe2-3e7f1987bfc5
DOI: 10.21203/rs.3.rs-2125381/v1

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