Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

UNC13A in amyotrophic lateral sclerosis: from genetic association to therapeutic target

3 Feb 2023

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited treatment options and an incompletely understood pathophysiology. Although genomewide association studies (GWAS) have advanced our understanding of the disease, the precise manner in which risk polymorphisms contribute to disease pathogenesis remains unclear. Of relevance, GWAS have shown that a polymorphism (rs12608932) in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Neurological diseases and metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prion Diseases and Protein Misfolding

Source

Identifiers

PMID: 36737245
DOI: 10.1136/jnnp-2022-330504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

UNC13A in amyotrophic lateral sclerosis: from genetic association to therapeutic targetPMID 36737245Read ↗

UNC13A is a modifier of survival in amyotrophic lateral sclerosis.Semantic proximity Read ↗

The Distinct Traits of the UNC13A Polymorphism in Amyotrophic Lateral Sclerosis.Semantic proximity Read ↗

Association of UNC13A with increased amyotrophic lateral sclerosis risk, bulbar onset, and lower motor neuron involvement in a Norwegian ALS cohort.Semantic proximity Read ↗

Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.Semantic proximity Read ↗

C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis.Semantic proximity Read ↗

Amyotrophic lateral sclerosis: recent genetic highlights.Semantic proximity Read ↗

Lithium carbonate in Amyotrophic Lateral Sclerosis patients homozygous for the C-allele at SNP rs12608932 in UNC13A; protocol for a confirmatory, randomized, group-sequential, event-driven, double-blind, placebo-controlled trial.Semantic proximity Read ↗

Update on genetics of amyotrophic lateral sclerosis.Semantic proximity Read ↗

TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A.Semantic proximity Read ↗

Clinical and Metabolic Signature of UNC13A rs12608932 Variant in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

UNC13A Gene Brings New Hope for ALS Disease-Modifying Drugs.Semantic proximity Read ↗

Lithium carbonate in amyotrophic lateral sclerosis patients homozygous for the C-allele at SNP rs12608932 in UNC13A: protocol for a confirmatory, randomized, group-sequential, event-driven, double-blind, placebo-controlled trial.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.