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Lithium Chloride Inhibits Iron Dysregulation and Ferroptosis in Induced Pluripotent Stem Cells with ApoE4/E4 from a sporadic Alzheimer’s disease patient

2025-09-02

Abstract excerpt

Alzheimer’s disease (AD), particularly its sporadic form (SAD, 95% AD patients), is strongly associated with the apolipoprotein E4 ApoE4 genotype and characterized by oxidative stress, iron dysregulation, and increased susceptibility to ferroptosis. Lithium, a well-established neuroprotective agent, has shown potential to mitigate several pathological mechanisms in AD, including ferroptosis. This study investigate...

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Literature Corpus work
3f98f8f0-186b-5912-91c1-40fe9b9c3aab
DOI
10.1101/2025.08.28.672956
Open publication

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Lithium Chloride Inhibits Iron Dysregulation and Ferroptosis in Induced Pluripotent Stem Cells with ApoE4/E4 from a sporadic Alzheimer’s disease patientDOI 10.1101/2025.08.28.672956
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