Article

Structural and transcriptomic alterations underlying the progression of aortic dissection in Fbn1G234D/G234D mice

2026-03-03

Abstract excerpt

<title>Abstract</title> <p>Aortic dissection (AD) is characterized by separation within the medial layers of the aortic wall. Pathogenic variants in the fibrillin-1 gene (FBN1), which cause Marfan syndrome, represent a major genetic cause of AD. In a recently established Fbn1G234D/G234D mouse model, intimomedial tears develop at 3 weeks of age, and 50% of mice die by 5 weeks from aortic rupture. Despite this seve...

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Literature Corpus work: fd6dbc6a-6cd2-577e-a042-e8711523cdf1
DOI: 10.21203/rs.3.rs-8556610/v1

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