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Article

Characterization of the proteome, diseases and evolution of the human postsynaptic density.

Nature neuroscience - 1 Jan 2011

Bayés Alex, van de Lagemaat Louie N, Collins Mark O, Croning Mike D R, Whittle Ian R, Choudhary Jyoti S, Grant Seth G N

Abstract excerpt

We isolated the postsynaptic density from human neocortex (hPSD) and identified 1,461 proteins. hPSD mutations cause 133 neurological and psychiatric diseases and were enriched in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation in mamma...

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Identifiers

PMID: 21170055
DOI: 10.1038/nn.2719
PMCID: PMC3040565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21170055-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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