Article

Tau Accumulation <i>via</i> Reduced BAG3-mediated Autophagy Is Required for GGGGCC Repeat Expansion-Induced Neurodegeneration

2019-08-06

Abstract excerpt

<h4>SUMMARY</h4> Expansions of trinucleotide or hexanucleotide repeats lead to several neurodegenerative disorders including Huntington disease (HD, caused by the expanded CAG repeats ( CAGr ) in the HTT gene) and amyotrophic lateral sclerosis (ALS, could be caused by the expanded GGGGCC repeats ( G4C2r ) in the C9ORF72 gene), of which the molecular mechanisms remain unclear. Here we demonstrate that loss of...

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Literature Corpus work: fd20231b-b93a-55af-a8df-bd010f9384ea
DOI: 10.1101/727008

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